Tandem repeats in human disorders: mechanisms and evolution.

Editorial: Could Speciation Across Evolution be Governed by Genetic Switch Codes at Short Tandem Repeats?

P-157: Polymorphic Core Promoter GA-repeats Alter Gene Expression of The Early Embryonic Developmental Genes

Background: We examine the GA-repeat core promoters of MECOM and GABRA3 in human embryonic kidney-293 cell line and show that those GA-repeats have promoter activity,and those different alleles of the repeats can significantly alter gene expression.We propose a novel role for GA-repeat core promoters to regulate gene expression in the genes involved in development and evolution. Materials and M...

Expandable DNA Repeat and Human Hereditary Disorders

Background & Aims: Nearly 30 hereditary disorders in humans result from an increase in the number of copies of simple repeats in genomic DNA, including fragile X syndrome, myotonic dystrophy, Huntington’s disease, and Friedreich’s ataxia. One the most frequently occurring types of mutation is trinucleotide repeat expansion. The present study was conducted with the aim of investigating the cause...

Tandem Repeats in 44 Prokaryotic Genomes and Genome Evolution

Genomes are full of various types of repetitive sequences, such as microsatelite, minisatelite, interspersed repeats, tandem repeats, and so on. These repetitive sequences are replete with information that would bring about a better understanding of not only genome evolution but also gene evolution. A tandem repeat (TR) is a DNA sequence piece containing two or more consecutive homologous eleme...

TITLE PAGE Comparative analyses of human single- and multi-locus tandem repeats

Using the compiled human genome sequence, we systematically catalogued all tandem repeats with periods between 20 and 2000 bp and defined two subsets whose consensus sequences were found at either single (slTRs) or multiple loci (mlTRs). Parameters compiled for these subsets provide insights into mechanisms underlying the creation and evolution of tandem repeats. Both subsets of tandem repeats ...

Mining the Association Rules of Transcription Factor Binding Sites in Human Tandem Repeats Using Aprior Algorithm

Tandem repeats (TR) are the most abundant ones in the extragenic region of genomes. Biologists have already found a large number of regulatory elements in this region. These elements may profoundly impact the chromatin structure formation in nucleus and also contain important clues in genetic evolution and phylogenic study. This study attempts to mine rules on how combinations of individual bin...